SCHEMBL7293159

SCHEMBL7293159

Nc1ccc2c(c1)CC(CC(=O)C1C(=S)CN[C@@H]1C(=O)N1CCCC1)C2

nearest known ligand 0.37

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PREP P48147 12/20 0.37
BRD4 O60885 1/20 0.33
ATAD2 Q6PL18 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7302992 0.88 DPP4 (0.41) PREP
SCHEMBL7296373 0.88 DPP4 (0.41) PREP
SCHEMBL7292981 0.87 PREP (0.48) PREP
SCHEMBL7292691 0.85 PSEN1 (0.30)
SCHEMBL7292258 0.85 PNMT (0.43)
SCHEMBL7302246 0.81 PREP (0.54) PREP
SCHEMBL7296356 0.81 PREP (0.54) PREP
SCHEMBL7294240 0.81 PREP (0.54) PREP
SCHEMBL7293165 0.80 PREP (0.40) PREPBRD4ATAD2
SCHEMBL7295069 0.79 CYP26A1 (0.42) PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6017929-A Cholinesterase activator ZERIA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed
EP-0754454-A1 CHOLINESTERASE ACTIVATOR ZERIA PHARMACEUTICAL CO., LTD. (JP) 1997-01-22 EP disclosed
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed