Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27761857 | 0.86 | CTBP2 (0.55) | CTBP2MEN1KMT2ACYP1A2USP2 | |
| SCHEMBL6441998 | 0.84 | MEN1 (0.54) | CTBP2MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL6499293 | 0.84 | FFAR1 (0.51) | CTBP2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6670971 | 0.83 | CTBP2 (0.68) | CTBP2MEN1KMT2ACYP1A2USP2 | |
| SCHEMBL29824310 | 0.83 | PTGS1 (0.67) | CTBP2MEN1KMT2ACYP1A2USP2 | |
| SCHEMBL229067 | 0.83 | PTGS1 (0.67) | CTBP2MEN1KMT2ACYP1A2USP2 | |
| SCHEMBL3423556 | 0.82 | CTBP2 (0.44) | CTBP2CYP1A2 | |
| SCHEMBL29846895 | 0.82 | CTBP2 (0.51) | CTBP2MEN1KMT2ACYP1A2POLB | |
| SCHEMBL1621499 | 0.82 | HDAC1 (0.58) | CTBP2MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL7341455 | 0.82 | CTBP2 (0.51) | CTBP2MEN1KMT2ACYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109369637-A | The novel derivative of kojic acid of one kind thiadiazoles containing 1,3,4- and its application | 湖南科技大学 | 2019-02-22 | — | — | CN | disclosed |
| EP-0636621-B1 | Beta-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1997-03-12 | — | — | EP | disclosed |
| US-5506259-A | β-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1996-04-09 | — | — | US | disclosed |
| US-5389616-A | Renin inhibitor, hypotensive agent | HOFFMAN-LAROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| EP-0636621-A1 | Beta-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |
| US-5256645-A | Renin inhibitors; hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5134123-A | Renin enzyme inhibitors for cardiovascular disorders and high blood pressure | HOFFMAN-LA ROCHE INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0332008-A2 | Peptide-like aminoacid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-09-13 | — | — | EP | disclosed |