SCHEMBL7293289

SCHEMBL7293289

BrCC1Cc2cc(OCc3ccccc3)ccc2O1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.51
MAOA P21397 8/20 0.51
HTR6 P50406 1/20 0.45
HRH3 Q9Y5N1 3/20 0.45
ITGB3 P05106 1/20 0.44
ITGA2B P08514 1/20 0.44
NPC1 O15118 1/20 0.44
ALDH1A1 P00352 1/20 0.44
HPGD P15428 1/20 0.44
NFKB1 P19838 1/20 0.44
GRM5 P41594 1/20 0.44
RAB9A P51151 1/20 0.44
NFKB2 Q00653 1/20 0.44
RELA Q04206 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
ALOX5 P09917 1/20 0.44
CA2 P00918 1/20 0.43
CA5A P35218 1/20 0.43
KDM1A O60341 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7293295 1.00 MAOB (0.51) MAOBMAOAHTR6HRH3ITGB3
SCHEMBL27395867 0.90 MAOB (0.49) MAOBMAOAHTR6HRH3ITGB3
SCHEMBL7288097 0.88 ITGB3 (0.56) MAOBMAOAHTR6HRH3ITGB3
SCHEMBL7288088 0.88 ITGB3 (0.56) MAOBMAOAHTR6HRH3ITGB3
SCHEMBL21198799 0.81 MAOB (0.60) MAOBMAOAHTR6NPC1ALDH1A1
SCHEMBL7312343 0.81 HTR6 (0.66) MAOBMAOAHTR6HRH3ITGB3
SCHEMBL7112912 0.81 HTR6 (0.66) MAOBMAOAHTR6HRH3ITGB3
SCHEMBL21198798 0.81 MAOB (0.60) MAOBMAOAHTR6NPC1ALDH1A1
SCHEMBL27416774 0.80 ITGB3 (0.53) MAOBMAOAHTR6HRH3ITGB3
SCHEMBL12502781 0.77 HTR6 (0.59) MAOBMAOAHTR6HRH3ITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6359138-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2002-03-19 US disclosed
EP-0846683-B1 4-Hydroxy-piperidine derivatives HOFFMANN LA ROCHE (CH) 2001-09-19 EP disclosed
EP-0846683-A1 4-Hydroxy-piperidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1998-06-10 EP disclosed