Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.81 |
| ▸ | TSHR | P16473 | 4/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | CRHBP | P24387 | 1/20 | 0.81 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | CASP1 | P29466 | 2/20 | 0.62 |
| ▸ | CASP7 | P55210 | 2/20 | 0.62 |
| ▸ | AHR | P35869 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638013 | 0.79 | TSHR (0.73) | KDM4EHSD17B10TSHRCYP1A2CRHBP | |
| SCHEMBL31087262 | 0.77 | MAPK1 (0.74) | KDM4EHSD17B10TSHRKMT2AMAPT | |
| SCHEMBL21880903 | 0.77 | RAB9A (1.00) | KDM4EHSD17B10TSHRKMT2AMAPT | |
| SCHEMBL11687989 | 0.77 | KDM4E (0.66) | KDM4EHSD17B10TSHRCYP1A2CRHBP | |
| SCHEMBL20188060 | 0.76 | TSHR (0.74) | KDM4EHSD17B10TSHRCYP1A2CRHBP | |
| SCHEMBL11316186 | 0.76 | HSD17B10 (0.73) | KDM4EHSD17B10TSHRCYP1A2CRHBP | |
| SCHEMBL20647549 | 0.75 | HTT (0.56) | KDM4EHSD17B10KMT2AMAPTLMNA | |
| SCHEMBL5691055 | 0.75 | RAB9A (0.63) | KDM4EHSD17B10TSHRCYP1A2CRHBP | |
| SCHEMBL12214430 | 0.74 | RAB9A (1.00) | KDM4EHSD17B10TSHRCYP1A2CRHBP | |
| SCHEMBL2624525 | 0.74 | MAPT (0.76) | KDM4EHSD17B10TSHRCYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343574-B1 | 4(1H)-quinolone derivatives | KIRIN BREWERY (JP) | 1994-07-27 | — | — | EP | disclosed |
| US-5081121-A | Cardiotonic agents | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0343574-A1 | 4(1H)-quinolone derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1989-11-29 | — | — | EP | disclosed |