Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698442 | 0.94 | — | — | |
| SCHEMBL321670 | 0.94 | — | — | |
| SCHEMBL1698570 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL3538913 | 0.92 | ALDH1A1 (0.51) | ALDH1A1HPGDLMNAPOLBUSP2 | |
| Water SCHEMBL28237304 | 0.92 | ALDH1A1 (0.51) | ALDH1A1HPGDLMNAPOLBUSP2 | |
| Chloroform SCHEMBL963008 | 0.90 | ALDH1A1 (0.47) | ALDH1A1HPGDLMNAPOLBUSP2 | |
| SCHEMBL9694657 | 0.89 | ALDH1A1 (0.44) | ALDH1A1HPGDLMNAPOLBUSP2 | |
| Methyl Alcohol SCHEMBL28090165 | 0.88 | ALDH1A1 (0.49) | ALDH1A1HPGDLMNAPOLBUSP2 | |
| SCHEMBL1967881 | 0.88 | ALDH1A1 (0.47) | ALDH1A1HPGDLMNAPOLBUSP2 | |
| SCHEMBL12080775 | 0.88 | ALDH1A1 (0.47) | ALDH1A1HPGDLMNAPOLBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| EP-0432984-B1 | Carbamoyl derivatives | ZENECA LTD (GB) | 1998-03-04 | — | — | EP | disclosed |
| EP-0630382-B1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1997-02-26 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0630382-A1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY. | ZENECA LTD (GB) | 1994-12-28 | — | — | EP | disclosed |
| US-5334765-A | Intermediate for leukotriene antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-08-02 | — | — | US | disclosed |
| US-5286740-A | Leukotrine antagonists; antiinflammatory agnets, antiallergens, treating asthma | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-15 | — | — | US | disclosed |
| US-5274118-A | Process for preparing (2R)-methyl-4,4,4-trifluorobutylamine | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-28 | — | — | US | disclosed |
| WO-1993021212-A1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |
| EP-0432984-A2 | Carbamoyl derivatives | ZENECA LIMITED (GB) | 1991-06-19 | — | — | EP | disclosed |
| US-4797391-A | TREATMENT OF TRAUMA TO THE BRAIN | MERCK & CO., INC. (US) | 1989-01-10 | — | — | US | disclosed |
| US-4777281-A | ANTIEDEMIC AGENTS; BRAIN INJURIES | MERCK & CO., INC. (US) | 1988-10-11 | — | — | US | disclosed |
| US-4622339-A | ANTICOAGULANTS, ANTIISCHEMIC, ANTIATHEROSCLEROTICS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-11-11 | — | — | US | disclosed |
| EP-0044711-B1 | 9,11-METHANO-13-AZA-11A-CARBATHROMBANOIC ACID ANALOGUES AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 1984-03-14 | — | — | EP | disclosed |
| US-4389413-A | 9,11-Methano-13-aza-11a-carbathrombanoic acid analogues | ONO PHARMACEUTICAL CO. LTD. (JP) | 1983-06-21 | — | — | US | disclosed |
| EP-0044711-A1 | 9,11-Methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-01-27 | — | — | EP | disclosed |
| US-4178367-A | Prostaglandin I2 analogues | ONO PHARMACEUTICAL CO. LTD. (JP) | 1979-12-11 | — | — | US | disclosed |