Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RASGRP1 | O95267 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300604 | 0.87 | HTR4 (0.69) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL7300751 | 0.83 | HTR4 (0.73) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL22414037 | 0.82 | SLC6A4 (0.63) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL9341467 | 0.81 | HTR4 (0.71) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL7300517 | 0.81 | HTR4 (0.71) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL7301147 | 0.80 | HTR4 (0.69) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL9344429 | 0.80 | HTR4 (0.67) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL9572993 | 0.80 | SLC6A4 (0.59) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL7293786 | 0.79 | HTR4 (0.68) | HTR4NPSR1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL18413857 | 0.79 | SLC6A4 (0.56) | HTR4NPSR1CYP1A2CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501322-B1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LTD (GB) | 1996-09-04 | — | — | EP | disclosed |
| CN-1083059-A | The indoles that 3-piperidine methyl carboxylicesters replaces | GLAXO GROUP LTD (GB) | 1994-03-02 | — | — | CN | disclosed |
| WO-1992014727-A1 | 3-PIPERIDINYLMETHYLCARBOXYLATE SUBSTITUTED INDOLES | GLAXO GROUP LIMITED (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0501322-A1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LIMITED (GB) | 1992-09-02 | — | — | EP | disclosed |