Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294493 | 1.00 | AKT1 (0.35) | AKT1POLBHCAR2KDM4ECHRNB2 | |
| SCHEMBL7293349 | 0.82 | ALDH1A1 (0.40) | AKT1POLBHCAR2KDM4ECHRNB2 | |
| SCHEMBL8016620 | 0.82 | CHRNB2 (0.39) | AKT1POLBHCAR2KDM4ECHRNB2 | |
| SCHEMBL7293345 | 0.82 | ALDH1A1 (0.40) | AKT1POLBHCAR2KDM4ECHRNB2 | |
| SCHEMBL6558937 | 0.79 | CHRNB2 (0.37) | AKT1POLBHCAR2KDM4ECHRNB2 | |
| SCHEMBL3016752 | 0.75 | CHRNB2 (0.43) | AKT1POLBHCAR2KDM4ECHRNB2 | |
| SCHEMBL16196075 | 0.75 | RAF1 (0.33) | AKT1POLBHCAR2KDM4ECHRNB2 | |
| SCHEMBL3016756 | 0.75 | CHRNB2 (0.43) | AKT1POLBHCAR2KDM4ECHRNB2 | |
| SCHEMBL5701203 | 0.75 | CHRNB2 (0.61) | AKT1KDM4ECHRNB2CHRNA4CHRNB4 | |
| SCHEMBL16196077 | 0.75 | RAF1 (0.33) | AKT1POLBHCAR2KDM4ECHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511865-B1 | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents | AMERICAN HOME PROD (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5250700-A | Phosphodiesterase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| US-5191084-A | PHENYL PYRAZOLIDINONES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0511865-A1 | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-11-04 | — | — | EP | disclosed |