Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292065 | 0.92 | HTT (0.37) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7291459 | 0.92 | CNR2 (0.36) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7289330 | 0.91 | MIF (0.34) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7287387 | 0.91 | GAA (0.34) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7286210 | 0.91 | GABRP (0.41) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL10569584 | 0.91 | KDM4E (0.38) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7288071 | 0.89 | KMT2A (0.43) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7290542 | 0.88 | MAPT (0.41) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7286216 | 0.88 | IDO1 (0.34) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL10562323 | 0.87 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1250383-A | — | — | None | — | — | JP | disclosed |
| EP-0281045-B1 | BENZOTHIEPINO (5,4-C) PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1991-12-27 | — | — | EP | disclosed |
| JP-H01250383-A | BENZOTHIEPINO(5,4-C)PYRIDAZINE COMPOUND | YOSHITOMI PHARMACEUT IND LTD | 1989-10-05 | — | — | JP | disclosed |
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0281045-A1 | Benzothiepino (5,4-c) pyridazine compounds and their pharmaceutical uses | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-09-07 | — | — | EP | disclosed |