Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308328 | 0.94 | LMNA (0.56) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL10965995 | 0.87 | MAPT (0.72) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL10967557 | 0.84 | MAPT (0.56) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL6795295 | 0.84 | MAPT (0.75) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL10967061 | 0.81 | SMN1; SMN2 (0.51) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL5309374 | 0.80 | PDE3B (0.63) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL11632296 | 0.79 | SMN1; SMN2 (0.54) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL4900340 | 0.79 | PDE3B (0.55) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL7296314 | 0.78 | PDE3B (0.57) | MAPTLMNANPY1RNPY2RSMN1; SMN2 | |
| SCHEMBL7306239 | 0.77 | LMNA (0.78) | MAPTLMNANPY1RNPY2RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |