Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287427 | 0.89 | PBRM1 (0.45) | MAPK1PBRM1ELANEATMTDP1 | |
| SCHEMBL3365804 | 0.88 | MAPK1 (0.46) | MAPK1PBRM1ATMTDP1L3MBTL1 | |
| SCHEMBL9583146 | 0.84 | LTA4H (0.42) | MAPK1ELANEL3MBTL1MAPTPTGS2 | |
| SCHEMBL3365800 | 0.82 | PBRM1 (0.44) | MAPK1PBRM1ATMTDP1L3MBTL1 | |
| SCHEMBL7297457 | 0.80 | MAPK1 (0.56) | MAPK1ELANEATMTDP1L3MBTL1 | |
| SCHEMBL7289769 | 0.78 | ALDH1A1 (0.43) | MAPK1L3MBTL1MAPK13MAPK12MAPK11 | |
| SCHEMBL7288617 | 0.78 | SRD5A2 (0.42) | MAPK1TDP1L3MBTL1POLBMAPT | |
| SCHEMBL7290225 | 0.78 | HDAC2 (0.39) | ATMALDH1A1SMN1; SMN2 | |
| SCHEMBL7296168 | 0.78 | MAPT (0.43) | MAPK1POLBMAPTPTGS2PTGS1 | |
| SCHEMBL3362438 | 0.78 | BACE1 (0.53) | ATMALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406958-B1 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-03-15 | — | — | EP | disclosed |
| EP-0406958-A2 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-09 | — | — | EP | disclosed |