Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.34 |
| ▸ | SHBG | P04278 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319672 | 1.00 | TP53 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL7304692 | 1.00 | TP53 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL9746111 | 1.00 | TP53 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL9822844 | 0.98 | KDM4E (0.42) | TP53KDM4EGMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL9823332 | 0.98 | KDM4E (0.42) | TP53KDM4EGMNNLMNAMAPT | |
| Acetic Acid SCHEMBL9744757 | 0.92 | ALDH1A1 (0.37) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL7317494 | 0.86 | TP53 (0.42) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL13995102 | 0.86 | EPHX1 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL13995101 | 0.86 | EPHX1 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL13995117 | 0.83 | ALDH1A1 (0.39) | TP53KDM4EGMNNLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0349922-A2 | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | claimed |
| EP-0349921-A2 | Etheral n-terminal aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | claimed |
| EP-0310072-A2 | Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents | G.D. Searle & Co. (US) | 1989-04-05 | — | — | EP | claimed |
| US-5180744-A | Renin inhibitors; hypotensive agents | G. D. SEARLE & CO. (US) | 1993-01-19 | — | — | US | disclosed |
| EP-0410260-A2 | Peptidyl aminodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-01-30 | — | — | EP | disclosed |
| EP-0355331-A2 | Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-02-28 | — | — | EP | disclosed |
| EP-0349922-A2 | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0349921-A2 | Etheral n-terminal aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0310072-A2 | Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents | G.D. Searle & Co. (US) | 1989-04-05 | — | — | EP | disclosed |