Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.34 |
| ▸ | SHBG | P04278 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295223 | 1.00 | TP53 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL7319672 | 1.00 | TP53 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL9746111 | 1.00 | TP53 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL9822844 | 0.98 | KDM4E (0.42) | TP53KDM4EGMNNLMNAMAPT | |
| Hydrochloric Acid SCHEMBL9823332 | 0.98 | KDM4E (0.42) | TP53KDM4EGMNNLMNAMAPT | |
| Acetic Acid SCHEMBL9744757 | 0.92 | ALDH1A1 (0.37) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL7317494 | 0.86 | TP53 (0.42) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL13995102 | 0.86 | EPHX1 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL13995101 | 0.86 | EPHX1 (0.41) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL13995117 | 0.83 | ALDH1A1 (0.39) | TP53KDM4EGMNNLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992000972-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-01-23 | — | — | WO | claimed |
| EP-0439556-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | claimed |
| WO-1990004917-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-05-17 | — | — | WO | claimed |
| US-5212175-A | Benzothiophenyl benzothiophenylalkyl-N-terminal amino hydroxy β-amino acid derivatives | G. D. SEARLE & CO. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| WO-1992000972-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-01-23 | — | — | WO | disclosed |
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |
| US-5059589-A | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0439556-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1990004917-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-05-17 | — | — | WO | disclosed |
| EP-0365992-A1 | Heterocyclic peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-05-02 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0295294-A4 | PEPTIDYLAMINODIOLS. | ABBOTT LAB (US) | 1990-04-10 | — | — | EP | disclosed |
| EP-0295294-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-12-21 | — | — | EP | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |