Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | VHL | P40337 | 1/20 | 0.37 |
| ▸ | ELOC | Q15369 | 1/20 | 0.37 |
| ▸ | ELOB | Q15370 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287890 | 0.94 | RYR2 (0.40) | APPGRM5MEN1KMT2AATM | |
| SCHEMBL7286803 | 0.91 | VHL (0.42) | VHLELOCELOBGRM5MEN1 | |
| SCHEMBL7298130 | 0.88 | KMT2A (0.39) | APPGRM5MEN1KMT2AATM | |
| SCHEMBL7290542 | 0.86 | MAPT (0.41) | APPMEN1KMT2AATMMAPT | |
| SCHEMBL7297582 | 0.86 | MAPT (0.41) | VHLELOCELOBGRM5MEN1 | |
| SCHEMBL10559167 | 0.84 | AMY1A (0.40) | APPGRM5MEN1KMT2AMAPT | |
| SCHEMBL7288749 | 0.83 | GRM5 (0.36) | VHLELOCELOBGRM5MEN1 | |
| SCHEMBL7287753 | 0.82 | MAPT (0.39) | VHLELOCELOBGRM5MEN1 | |
| SCHEMBL7286064 | 0.82 | MAPT (0.39) | VHLELOCELOBGRM5MEN1 | |
| SCHEMBL10560262 | 0.81 | APP (0.42) | APPMEN1KMT2AATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281045-B1 | BENZOTHIEPINO (5,4-C) PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0281045-A1 | Benzothiepino (5,4-c) pyridazine compounds and their pharmaceutical uses | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-09-07 | — | — | EP | disclosed |