Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286064 | 0.95 | MAPT (0.39) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7286803 | 0.91 | VHL (0.42) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7286210 | 0.89 | GABRP (0.41) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7297582 | 0.86 | MAPT (0.41) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7288749 | 0.85 | GRM5 (0.36) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7287890 | 0.82 | RYR2 (0.40) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7295253 | 0.82 | APP (0.38) | MAPTALDH1A1KMT2AMEN1VHL | |
| SCHEMBL7288071 | 0.82 | KMT2A (0.43) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7290309 | 0.81 | ALDH1A1 (0.41) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7289175 | 0.81 | MAPT (0.41) | MAPTALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281045-B1 | BENZOTHIEPINO (5,4-C) PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |