Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295644 | 1.00 | HDAC8 (0.51) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL8998354 | 0.92 | ALDH1A1 (0.45) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL7306680 | 0.92 | ALDH1A1 (0.45) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL8998365 | 0.92 | ALDH1A1 (0.45) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL9097302 | 0.91 | ALDH1A1 (0.48) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL9097666 | 0.91 | HRH2 (0.48) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL9097298 | 0.91 | ALDH1A1 (0.48) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL9097662 | 0.91 | HRH2 (0.48) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL7306599 | 0.91 | PREP (0.50) | HDAC8MEN1KMT2AHRH2HRH1 | |
| SCHEMBL7306610 | 0.91 | PREP (0.50) | HDAC8MEN1KMT2AHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506256-A | PREVENTION AND/OR TREATMENT OF DEMENTIA, AMNESIA | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0468469-A2 | Proline derivatives | Japan Tobacco Inc. (JP) | 1992-01-29 | — | — | EP | disclosed |