Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8998365 | 1.00 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AHRH2HRH1 | |
| SCHEMBL8998354 | 1.00 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AHRH2HRH1 | |
| SCHEMBL7295644 | 0.92 | HDAC8 (0.51) | MEN1KMT2AHRH2HRH1KDM4E | |
| SCHEMBL7295642 | 0.92 | HDAC8 (0.51) | MEN1KMT2AHRH2HRH1KDM4E | |
| SCHEMBL9096533 | 0.90 | KMT2A (0.45) | MEN1KMT2AHRH2HRH1GPR119 | |
| SCHEMBL9094788 | 0.90 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AHRH2HRH1 | |
| SCHEMBL7297691 | 0.90 | KLK7 (0.46) | ALDH1A1MEN1KMT2AHRH2HRH1 | |
| SCHEMBL18336855 | 0.90 | KLK7 (0.46) | ALDH1A1MEN1KMT2AHRH2HRH1 | |
| SCHEMBL9096522 | 0.86 | KLK7 (0.51) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL7300593 | 0.84 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AKDM4EHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536737-A | Compound having prolyl endopeptidase inhibitory activity and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5506256-A | PREVENTION AND/OR TREATMENT OF DEMENTIA, AMNESIA | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0670309-A1 | COMPOUND WITH PROLYL ENDOPEPTIDASE INHIBITOR ACTIVITY AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 1995-09-06 | — | — | EP | disclosed |
| EP-0468469-A2 | Proline derivatives | Japan Tobacco Inc. (JP) | 1992-01-29 | — | — | EP | disclosed |