Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2359195 | 1.00 | MMP12 (0.34) | MMP12HSP90AA1MAPTBACE1BTN3A1 | |
| SCHEMBL7302414 | 1.00 | MMP12 (0.34) | MMP12HSP90AA1MAPTBACE1BTN3A1 | |
| SCHEMBL5504733 | 0.90 | POLB (0.37) | HSP90AA1BACE1BTN3A1TSHR | |
| SCHEMBL2345036 | 0.90 | POLB (0.37) | HSP90AA1BACE1BTN3A1TSHR | |
| SCHEMBL16405292 | 0.89 | BTN3A1 (0.33) | HSP90AA1BTN3A1TSHR | |
| SCHEMBL16401537 | 0.89 | BTN3A1 (0.33) | HSP90AA1BTN3A1TSHR | |
| SCHEMBL14700385 | 0.88 | ALDH1A1 (0.44) | MAPTTSHR | |
| SCHEMBL13847571 | 0.87 | HSP90AA1 (0.32) | HSP90AA1BTN3A1TSHR | |
| SCHEMBL1408508 | 0.86 | HSP90AA1 (0.32) | HSP90AA1TSHR | |
| SCHEMBL12152091 | 0.86 | HSP90AA1 (0.32) | HSP90AA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0521471-B1 | Pyrimidine derivatives as HMG-CoA reductase inhibitors | SHIONOGI & CO (JP) | 2000-10-25 | — | — | EP | claimed |
| EP-0521471-A1 | Pyrimidine derivatives as HMG-CoA reductase inhibitors | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-01-07 | — | — | EP | claimed |