Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372875 | 0.93 | SIGMAR1 (0.50) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9371956 | 0.84 | SIGMAR1 (0.56) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7290398 | 0.83 | SIGMAR1 (0.55) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9378617 | 0.83 | SIGMAR1 (0.47) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7290222 | 0.81 | SIGMAR1 (0.53) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7289379 | 0.80 | ALDH1A1 (0.38) | SIGMAR1DRD2HSD11B1 | |
| SCHEMBL7289331 | 0.80 | SIGMAR1 (0.52) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7290957 | 0.80 | SIGMAR1 (0.52) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9373412 | 0.79 | SIGMAR1 (0.51) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7297445 | 0.78 | MEN1 (0.50) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412821-B1 | 1-oxa-2-oxo-3,8-diazaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and processes for preparing them | RICHTER GEDEON VEGYESZET (HU) | 1994-11-09 | — | — | EP | disclosed |
| EP-0413516-B1 | 4-Methylene-1-oxa-2-oxo-8-azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and processes for preparing them | RICHTER GEDEON VEGYESZET (HU) | 1994-04-20 | — | — | EP | disclosed |
| EP-0414422-B1 | 2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZET (HU) | 1994-04-06 | — | — | EP | disclosed |
| EP-0414421-B1 | 1-Oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZET (HU) | 1994-04-06 | — | — | EP | disclosed |
| EP-0412820-B1 | 2-Oxo-1-oxa-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZET (HU) | 1994-03-02 | — | — | EP | disclosed |
| US-5157038-A | Antidepressants; tranquilizers; treatment of schizophrenia and epilepsy; antilepmic agents | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1992-10-20 | — | — | US | disclosed |
| EP-0414421-A2 | 1-Oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-27 | — | — | EP | disclosed |
| EP-0414422-A2 | 2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-27 | — | — | EP | disclosed |
| EP-0413516-A2 | 4-Methylene-1-oxa-2-oxo-8-azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and processes for preparing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-20 | — | — | EP | disclosed |
| EP-0412821-A2 | 1-oxa-2-oxo-3,8-diazaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and processes for preparing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-13 | — | — | EP | disclosed |
| EP-0412820-A2 | 2-Oxo-1-oxa-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-13 | — | — | EP | disclosed |