Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ADH5 | P11766 | 1/20 | 0.48 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296217 | 1.00 | MAOB (0.57) | MAOBTBXAS1ESR1ALDH1A1RAB9A | |
| SCHEMBL1238620 | 0.83 | ESR1 (0.67) | MAOBTBXAS1ESR1ALDH1A1KMT2A | |
| SCHEMBL1238616 | 0.83 | ESR1 (0.67) | MAOBTBXAS1ESR1ALDH1A1KMT2A | |
| SCHEMBL3209590 | 0.83 | ENPP2 (0.62) | MAOBESR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3209577 | 0.83 | ENPP2 (0.62) | MAOBESR1ALDH1A1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7328757 | 0.82 | ESR1 (0.65) | MAOBTBXAS1ESR1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL7328751 | 0.82 | ESR1 (0.65) | MAOBTBXAS1ESR1ALDH1A1KMT2A | |
| SCHEMBL8828266 | 0.80 | MAOB (0.54) | MAOBTBXAS1ESR1ALDH1A1KMT2A | |
| SCHEMBL8828261 | 0.80 | MAOB (0.54) | MAOBTBXAS1ESR1ALDH1A1KMT2A | |
| SCHEMBL11015693 | 0.79 | TBXAS1 (0.44) | MAOBTBXAS1ESR1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599332-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |
| EP-0145450-A2 | 6- [2-[4-(1H-imidazol-1-yl)phenyl]-alkylene and alkylenyl]-3(2H)-pyridazinones, the 4,5-dihydro- pyridazinone derivatives thereof, and a process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |