Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.61 |
| ▸ | CCR2 | P41597 | 3/20 | 0.61 |
| ▸ | ITK | Q08881 | 2/20 | 0.55 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.47 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405680 | 0.85 | ROCK2 (0.62) | ROCK2ROCK1CCR2ITKMALT1 | |
| SCHEMBL4833796 | 0.83 | ROCK2 (0.64) | ROCK2ROCK1CCR2ITKACHE | |
| SCHEMBL5409256 | 0.81 | ROCK2 (0.83) | ROCK2ROCK1CCR2KDM4E | |
| Hydrochloric Acid SCHEMBL5409061 | 0.80 | ROCK2 (0.82) | ROCK2ROCK1CCR2KDM4E | |
| SCHEMBL8264491 | 0.79 | AR (0.51) | ROCK2ROCK1ITKKDM4E | |
| SCHEMBL4309421 | 0.77 | CNR1 (0.58) | ROCK2ROCK1ACHEKDM4EGAA | |
| SCHEMBL918426 | 0.77 | KDM4E (0.66) | ROCK2ROCK1CCR2MALT1ACHE | |
| SCHEMBL3319580 | 0.76 | ROCK2 (0.58) | ROCK2ROCK1CCR2ITKMALT1 | |
| SCHEMBL7286870 | 0.76 | KDM4E (0.67) | ROCK2ROCK1CCR2MALT1ACHE | |
| SCHEMBL923860 | 0.76 | LMNA (0.68) | ROCK2ROCK1CCR2MALT1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |