Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.63 |
| ▸ | CALML3 | P27482 | 6/20 | 0.60 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | FADS1 | O60427 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292822 | 0.88 | GRM2 (0.67) | GRM2CALML3FADS1SIGMAR1 | |
| SCHEMBL9549439 | 0.86 | GRM2 (0.64) | GRM2CALML3MAOAMAOBSIGMAR1 | |
| SCHEMBL9482302 | 0.86 | GRM2 (0.64) | GRM2CALML3MAOAMAOBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL11233573 | 0.84 | GRM2 (0.60) | GRM2CALML3MAOAMAOB | |
| SCHEMBL3327082 | 0.84 | MAOA (0.58) | GRM2CALML3MAOAMAOB | |
| SCHEMBL7300213 | 0.84 | GRM2 (0.63) | GRM2CALML3MAOAMAOBSIGMAR1 | |
| SCHEMBL12728919 | 0.84 | MAOA (0.70) | GRM2CALML3MAOAMAOBSIGMAR1 | |
| SCHEMBL3323919 | 0.84 | MAOA (0.58) | GRM2CALML3MAOAMAOB | |
| SCHEMBL412168 | 0.84 | MAOA (0.58) | GRM2CALML3MAOAMAOB | |
| SCHEMBL16809996 | 0.84 | MAOA (0.70) | GRM2CALML3MAOAMAOBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459256-B1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GMBH (DE) | 1995-07-12 | — | — | EP | disclosed |
| US-5232931-A | OXAZOLIDINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0300272-B1 | OXAZOLIDINONES | MERCK PATENT GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |
| EP-0459256-A1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GmbH (DE) | 1991-12-04 | — | — | EP | disclosed |
| US-4970217-A | NEUROLEPTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-11-13 | — | — | US | disclosed |
| EP-0300272-A1 | Oxazolidinones | MERCK PATENT GmbH (DE) | 1989-01-25 | — | — | EP | disclosed |