Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297472 | 1.00 | PREP (0.48) | PREPKMT2AMEN1F2ABCB1 | |
| SCHEMBL7305931 | 0.93 | PREP (0.48) | PREPF2ABCB1ACEDPP4 | |
| SCHEMBL7305938 | 0.93 | PREP (0.48) | PREPF2ABCB1ACEDPP4 | |
| SCHEMBL9097367 | 0.92 | ACE (0.49) | PREPF2TSHRACE | |
| SCHEMBL9097372 | 0.92 | ACE (0.49) | PREPF2TSHRACE | |
| SCHEMBL9097297 | 0.91 | F2 (0.49) | PREPF2ABCB1DRD4FKBP1A | |
| SCHEMBL9097291 | 0.91 | F2 (0.49) | PREPF2ABCB1DRD4FKBP1A | |
| SCHEMBL9098707 | 0.88 | CPT1A (0.52) | PREP | |
| SCHEMBL9098714 | 0.88 | CPT1A (0.52) | PREP | |
| SCHEMBL7305856 | 0.85 | PREP (0.68) | PREPKMT2AMEN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506256-A | PREVENTION AND/OR TREATMENT OF DEMENTIA, AMNESIA | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0468469-A2 | Proline derivatives | Japan Tobacco Inc. (JP) | 1992-01-29 | — | — | EP | disclosed |