Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746687 | 0.90 | ALDH1A1 (0.64) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL7354205 | 0.85 | MAPT (0.53) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL9570633 | 0.84 | MAPT (0.58) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL8811170 | 0.82 | MAPT (0.58) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL2769872 | 0.82 | MAPT (0.57) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL8683656 | 0.82 | ALDH1A1 (0.57) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL5280249 | 0.82 | MAPT (0.57) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL9395356 | 0.82 | MAPT (0.57) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL5657641 | 0.82 | MAPT (0.57) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL3646086 | 0.82 | MAPT (0.51) | MAPTALDH1A1POLBIDO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107628975-B | Lysine derivative histone deacetylases inhibitor and its synthesis and application | GUIZHOU MEDICAL UNIVERSITY (CN) | 2019-10-29 | — | — | CN | claimed |
| CN-107628975-A | Lysine derivative histone deacetylases inhibitor and synthesis and application | 贵州医科大学 | 2018-01-26 | — | — | CN | claimed |
| CN-107628975-B | Lysine derivative histone deacetylases inhibitor and its synthesis and application | GUIZHOU MEDICAL UNIVERSITY (CN) | 2019-10-29 | — | — | CN | disclosed |
| CN-107628975-A | Lysine derivative histone deacetylases inhibitor and synthesis and application | 贵州医科大学 | 2018-01-26 | — | — | CN | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |