Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790719 | 0.89 | MAPT (0.54) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL8746687 | 0.88 | ALDH1A1 (0.64) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL10484092 | 0.86 | MAPT (0.51) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL9570633 | 0.82 | MAPT (0.58) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL7297643 | 0.82 | MAPT (0.58) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL8811170 | 0.81 | MAPT (0.58) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL9395356 | 0.81 | MAPT (0.57) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL5657641 | 0.81 | MAPT (0.57) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL5280249 | 0.81 | MAPT (0.57) | MAPTALDH1A1POLBIDO1MEN1 | |
| SCHEMBL8683656 | 0.81 | ALDH1A1 (0.57) | MAPTALDH1A1POLBIDO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678162-B1 | P-GLYCOPROTEIN INHIBITOR, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | HANMI PHARM IND CO LTD (KR) | 2010-04-28 | — | — | EP | disclosed |
| US-7625926-B2 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same | HANMI PHARM. CO., LTD (KR) | 2009-12-01 | — | — | US | disclosed |
| EP-1678162-A4 | P-GLYCOPROTEIN INHIBITOR, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | HANMI PHARM IND CO LTD (KR) | 2008-07-02 | — | — | EP | disclosed |
| US-20070072900-A1 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same | HANMI PHARM. CO., LTD. (KR) | 2007-03-29 | — | — | US | disclosed |
| EP-1678162-A1 | P-GLYCOPROTEIN INHIBITOR, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Hanmi Pharm. Co., Ltd. (KR) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005033097-A1 | P-GLYCOPROTEIN INHIBITOR, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | HANMI PHARM. CO., LTD. (KR) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072900-A1 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same | ABCB1, ABCG2, ABCB11 | MAPT 2328/4885ALDH1A1 1108/4885POLB 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.