Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805631 | 0.93 | POLB (0.48) | NAMPTPOLBSMN1; SMN2HTTELANE | |
| SCHEMBL7294409 | 0.87 | LMNA (0.44) | NAMPTPOLBLMNASMN1; SMN2TP53 | |
| SCHEMBL8519576 | 0.87 | NPC1 (0.45) | POLBKMT2AMEN1ELANENPC1 | |
| SCHEMBL7294381 | 0.86 | ELANE (0.47) | POLBLMNASMN1; SMN2ALDH1A1ELANE | |
| SCHEMBL8614426 | 0.83 | ELANE (0.49) | NAMPTPOLBELANENPC1RAB9A | |
| SCHEMBL7293771 | 0.82 | ELANE (0.43) | POLBSMN1; SMN2ELANENPC1RAB9A | |
| SCHEMBL7297125 | 0.81 | NPC1 (0.44) | POLBSMN1; SMN2HTTELANENPC1 | |
| SCHEMBL7294413 | 0.77 | NAMPT (0.47) | NAMPTPOLBLMNAALDH1A1MAPT | |
| SCHEMBL7333984 | 0.75 | ELANE (0.45) | POLBELANENPC1RAB9A | |
| SCHEMBL7953850 | 0.75 | IDO1 (0.41) | NAMPTLMNAALDH1A1ELANETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |