Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293118 | 0.87 | ELANE (0.42) | ELANEHDAC3HDAC1HDAC2POLB | |
| SCHEMBL6805631 | 0.86 | POLB (0.48) | ELANEPOLBNPC1RAB9ACASP3 | |
| SCHEMBL7297829 | 0.82 | NAMPT (0.48) | ELANEPOLBNPC1RAB9ACASP3 | |
| SCHEMBL7294381 | 0.82 | ELANE (0.47) | ELANEPOLBNPC1RAB9ACASP3 | |
| SCHEMBL8519576 | 0.80 | NPC1 (0.45) | ELANEPOLBNPC1RAB9ACASP3 | |
| SCHEMBL8614426 | 0.79 | ELANE (0.49) | ELANEPOLBNPC1RAB9AROCK2 | |
| SCHEMBL7297125 | 0.76 | NPC1 (0.44) | ELANEPOLBNPC1RAB9ACASP3 | |
| SCHEMBL7293123 | 0.76 | HDAC3 (0.44) | ELANEHDAC3HDAC1HDAC2POLB | |
| SCHEMBL7333984 | 0.74 | ELANE (0.45) | ELANEPOLBNPC1RAB9AMAP3K5 | |
| SCHEMBL8401418 | 0.73 | NPC1 (0.51) | ELANEPOLBNPC1RAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528633-B1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| US-5254558-A | Substituted 1,3-diazines as leukocyte elastase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0528633-A1 | Pyrimidinyl acetamides as elastase inhibitors | ZENECA LIMITED (GB) | 1993-02-24 | — | — | EP | disclosed |