Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19912955 | 0.84 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1EPHX2LMNA | |
| SCHEMBL27281585 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1EPHX2HCAR2 | |
| SCHEMBL7297906 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1EPHX2LMNA | |
| SCHEMBL18673 | 0.82 | ALDH1A1 (0.68) | ALDH1A1MAPK1L3MBTL1EPHX2HCAR2 | |
| SCHEMBL7348870 | 0.81 | TGM2 (0.61) | L3MBTL1LMNAHTTMAPT | |
| SCHEMBL7526762 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPK1L3MBTL1EPHX2HCAR2 | |
| SCHEMBL15260919 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPK1L3MBTL1HCAR2LMNA | |
| SCHEMBL10030999 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1EPHX2LMNA | |
| SCHEMBL2926392 | 0.80 | ALDH1A1 (0.66) | ALDH1A1MAPK1L3MBTL1EPHX2HCAR2 | |
| SCHEMBL4941879 | 0.80 | ALDH1A1 (0.66) | ALDH1A1MAPK1L3MBTL1EPHX2HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |