Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.71 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11365346 | 0.90 | KCNH2 (0.86) | KCNH2CACNA1GKMT2AMAPTATM | |
| SCHEMBL20444278 | 0.86 | KMT2A (0.76) | KCNH2CACNA1GKMT2AMAPTATM | |
| SCHEMBL4864531 | 0.86 | KDM4E (0.74) | KMT2AMAPTATMMAPK1CYP2D6 | |
| SCHEMBL6754439 | 0.86 | USP2 (0.81) | KMT2AMAPTATMCYP2D6CYP2C19 | |
| SCHEMBL12402885 | 0.86 | ATM (0.61) | KCNH2CACNA1GKMT2AMAPTATM | |
| SCHEMBL12402888 | 0.86 | ATM (0.61) | KCNH2CACNA1GKMT2AMAPTATM | |
| SCHEMBL5754770 | 0.86 | TSHR (0.67) | KCNH2CACNA1GKMT2AMAPTATM | |
| SCHEMBL24322808 | 0.85 | L3MBTL1 (0.77) | KMT2AATMMAPK1CYP2D6CYP2C19 | |
| SCHEMBL5878421 | 0.85 | L3MBTL1 (0.77) | KMT2AATMMAPK1CYP2D6CYP2C19 | |
| SCHEMBL7953079 | 0.85 | ATM (0.85) | KCNH2CACNA1GKMT2AMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |
| US-4269838-A | ADRENERGIC BLOCKING AGENTS; ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS | NIPPON SHINYAKU CO. LTD. (JP) | 1981-05-26 | — | — | US | disclosed |