Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 2/20 | 0.31 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.30 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7298013 | 1.00 | PLA2G10 (0.41) | PLA2G10PLA2G5PKMGAAPOLB | |
| SCHEMBL8988818 | 0.87 | ACE (0.39) | PLA2G10PLA2G5PKMGAAPOLB | |
| SCHEMBL8988835 | 0.87 | ACE (0.39) | PLA2G10PLA2G5PKMGAAPOLB | |
| Oxalic Acid SCHEMBL7298168 | 0.85 | PLA2G10 (0.41) | PLA2G10PLA2G5PKMGAAPOLB | |
| Oxalic Acid SCHEMBL7298195 | 0.85 | PLA2G10 (0.41) | PLA2G10PLA2G5PKMGAAPOLB | |
| SCHEMBL7278907 | 0.84 | PLA2G10 (0.45) | PLA2G10PLA2G5PKMGAAPOLB | |
| Hydrochloric Acid SCHEMBL7278550 | 0.83 | PLA2G10 (0.44) | PLA2G10PLA2G5PKMGAAPOLB | |
| Oxalic Acid SCHEMBL7285955 | 0.81 | PLA2G10 (0.38) | PLA2G10PLA2G5PKMGAA | |
| Oxalic Acid SCHEMBL7285969 | 0.81 | PLA2G10 (0.38) | PLA2G10PLA2G5PKMGAA | |
| SCHEMBL7296969 | 0.81 | PLA2G10 (0.43) | PLA2G10PLA2G5PKMGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643072-B1 | 2-Piperazinone compounds and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-02-24 | — | — | EP | disclosed |
| EP-0643072-A1 | 2-Piperazinone compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | disclosed |