Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298373 | 1.00 | KMT2A (0.45) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL10522272 | 0.99 | KMT2A (0.44) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL7381948 | 0.90 | CYP1A2 (0.46) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL7299496 | 0.88 | TDP1 (0.47) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL7299487 | 0.88 | TDP1 (0.47) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL7383121 | 0.87 | TDP1 (0.45) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL7382129 | 0.86 | FPR2 (0.46) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL7376508 | 0.85 | MEN1 (0.42) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL7377136 | 0.84 | MEN1 (0.44) | KMT2AMEN1RAB9ANPC1CYP1A2 | |
| SCHEMBL7291448 | 0.83 | ACE (0.44) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0306879-A2 | Phosphonate and phosphonamide endopeptidase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1989-03-15 | — | — | EP | claimed |
| US-4963539-A | TREATING HEART FAILURE, PAIN OR DIARRHEA | E. R. SQUIBB & SONS, INC. (US) | 1990-10-16 | — | — | US | disclosed |
| EP-0306879-A2 | Phosphonate and phosphonamide endopeptidase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1989-03-15 | — | — | EP | disclosed |