Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142078 | 0.94 | ACHE (0.52) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8155554 | 0.92 | ACHE (0.52) | ACHEFAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL8155852 | 0.92 | ACHE (0.52) | ACHEFAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL2885528 | 0.87 | — | — | |
| SCHEMBL7570219 | 0.87 | ACHE (0.61) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21068069 | 0.87 | ACHE (0.61) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12417367 | 0.85 | ACHE (0.61) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27712904 | 0.85 | ACHE (0.61) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1023071 | 0.85 | ACHE (0.61) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7781306 | 0.85 | ACHE (0.61) | ACHEHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6041157-A | Environmentally sensitive compositions of matter based on 3H-fluoren-3-ylidenes and process for making same | GOETZ FREDERICK JAMES (US) | 2000-03-21 | — | — | US | disclosed |
| EP-0861832-A1 | Novel tetrahydropyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5410058-A | Exhibit high affinity and specificity to alpha receptors; useful in treating some psychoses | SHIONOGI & CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| US-5362873-A | Tetrahydropyridine derivatives | SHIONOGI & CO., LTD. (JP) | 1994-11-08 | — | — | US | disclosed |
| US-5243051-A | Treatment of psychological disorders | SHIONIGI & CO., LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| US-5149817-A | Psychotropic agents | SHIONOGI & CO., LTD. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445701-A1 | Novel tetrahydropyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |