SCHEMBL729873

SCHEMBL729873

O=C(O)N1CC(O)C(F)C1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 3/20 0.33
CHRNB2 P17787 8/20 0.32
CHRNA3 P32297 8/20 0.32
CHRNA4 P43681 8/20 0.32
CHRNB3 Q05901 4/20 0.32
CHRNA6 Q15825 4/20 0.32
DPP4 P27487 3/20 0.32
CHRNB4 P30926 4/20 0.31
CHRNA7 P36544 4/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17801566 1.00 LOXL2 (0.33) LOXL2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL29245359 1.00 LOXL2 (0.33) LOXL2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL16973076 1.00 LOXL2 (0.33) LOXL2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL17801599 1.00 LOXL2 (0.33) LOXL2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL20476090 1.00 LOXL2 (0.33) LOXL2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL18980410 0.85 DPP4 (0.41) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL14480018 0.85 DPP4 (0.41) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL29394234 0.83 CHRNB2 (0.33) LOXL2CHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL28026856 0.83 CHRNB2 (0.33) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL3184989 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12448368-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2025-10-21 US disclosed
US-20250236608-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION 2025-07-24 US disclosed
US-20250122176-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2025-04-17 US disclosed
US-20250092021-A9 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2025-03-20 US disclosed
CN-118019532-A Azetidine and pyrrolidine PARP1 inhibitors and uses thereof 新特拉有限公司 2024-05-10 CN disclosed
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2023-11-02 US disclosed
WO-2023133183-A1 KRAS INHIBITORS THERAS, INC. (US) 2023-07-13 WO disclosed
US-11667624-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2023-06-06 US disclosed
EP-4182320-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS Nido Biosciences, Inc. (US) 2023-05-24 EP disclosed
US-20230049406-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2023-02-16 US disclosed
WO-2014075392-A1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA MERCK SHARP & DOHME CORP. (US) 2014-05-22 WO disclosed
EP-2137184-B1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2013-05-08 EP disclosed
US-8138181-B2 Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors ARRAY BIOPHARMA INC. (US) 2012-03-20 US disclosed
US-20110201599-A1 CDK Modulators EXELIXIS, INC. (US) 2011-08-18 US disclosed
CN-102143746-A CDK modulators EXELIXIS INC 2011-08-03 CN disclosed
EP-2320895-A2 CDK MODULATORS Exelixis, Inc. (US) 2011-05-18 EP disclosed
US-20100029633-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2010-02-04 US disclosed
WO-2010003133-A2 CDK MODULATORS EXELIXIS INC. (US) 2010-01-07 WO disclosed
EP-2137184-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS Array Biopharma, Inc. (US) 2009-12-30 EP disclosed
WO-2008124323-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2008-10-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230049406-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 LOXL2 3127/4885CHRNB2 365/4885CHRNA3 140/4885
US-20100029633-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS PIM1, PIM3, PIM2 LOXL2 4527/4885CHRNB2 3290/4885CHRNA3 1958/4885
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 LOXL2 2985/4885CHRNB2 424/4885CHRNA3 152/4885
US-20250122176-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 LOXL2 3127/4885CHRNB2 365/4885CHRNA3 140/4885
US-11667624-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 LOXL2 3664/4885CHRNB2 332/4885CHRNA3 109/4885
US-20250092021-A9 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 LOXL2 3127/4885CHRNB2 365/4885CHRNA3 140/4885
US-20250236608-A1 EGFR INHIBITORS EGFR, ERBB2, ERBB3 LOXL2 2490/4885CHRNB2 4774/4885CHRNA3 4843/4885
US-20110201599-A1 CDK Modulators CDK3, CDK1, CDKL1 LOXL2 4639/4885CHRNB2 4463/4885CHRNA3 3952/4885
US-12448368-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 LOXL2 3664/4885CHRNB2 332/4885CHRNA3 109/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.