Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | CTSS | P25774 | 6/20 | 0.51 |
| ▸ | CTSK | P43235 | 5/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.49 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16345763 | 0.91 | ITGB3 (0.58) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL19138179 | 0.91 | ITGB3 (0.58) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL27231128 | 0.86 | ACE (0.64) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL19174463 | 0.86 | ITGB3 (0.60) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL16346172 | 0.83 | CTSS (0.57) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL27181207 | 0.83 | ITGB3 (0.57) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL27181211 | 0.83 | ITGB3 (0.57) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL1350138 | 0.82 | PTPN1 (0.62) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL3450109 | 0.82 | PTPN1 (0.62) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL1350140 | 0.82 | PTPN1 (0.62) | ITGB3ITGA2BACEPTPN1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0478328-B1 | Novel fibrinogen receptor antagonists | MERCK & CO INC (US) | 1996-01-10 | — | — | EP | claimed |
| EP-0478328-A1 | Novel fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-04-01 | — | — | EP | claimed |
| EP-0478328-B1 | Novel fibrinogen receptor antagonists | MERCK & CO INC (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0528586-B1 | Inhibiting osteoclast-mediated bone resorption using aminoalkyl-substituted phenyl derivatives | MERCK & CO INC (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5294616-A | Anticoagulants, inhibition of fibrinogen binding to blood platelets | MERCK & CO., INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5217994-A | METHOD OF INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION BY ADMINISTRATION OF AMINOALKYL-SUBSTITUTED PHENYL DERIVATIVES | MERCK & CO., INC. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5204350-A | Treating osteoporosis | MERCK & CO., INC. (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0528587-A1 | Inhibiting osteoclast-mediated bone resorption using substituted phenyl derivatives | MERCK & CO. INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| EP-0528586-A1 | Inhibiting osteoclast-mediated bone resorption using aminoalkyl-substituted phenyl derivatives | MERCK & CO. INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| EP-0478328-A1 | Novel fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-04-01 | — | — | EP | disclosed |