Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31276129 | 0.84 | HPGD (0.49) | HPGDTSHRMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL17876999 | 0.77 | HPGD (0.43) | HPGDTSHRMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL28866488 | 0.77 | HSP90AB1 (0.43) | MEN1KMT2ATDP1HSP90AB1ALDH1A1 | |
| SCHEMBL7225379 | 0.76 | HPGD (0.49) | HPGDTSHRMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL13666585 | 0.76 | HPGD (0.49) | HPGDTSHRMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL3048462 | 0.75 | POLB (0.39) | MEN1LMNAKMT2ATDP1HSP90AA1 | |
| SCHEMBL509012 | 0.75 | TSHR (0.57) | HPGDTSHRMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL272159 | 0.74 | ALDH1A1 (0.54) | HPGDTSHRMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL9890969 | 0.74 | POLB (0.38) | HPGDMAPK1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL1149742 | 0.74 | KDM4E (0.48) | HPGDMAPK1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550111-B1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-04-14 | — | — | EP | disclosed |
| EP-0550111-A1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0550112-A1 | 2-Saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and pharmaceutical compositions contaning them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |