Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16513026 | 0.86 | HTT (0.48) | HPGDHSP90AA1HSP90AB1MAPK1CYP1A2 | |
| SCHEMBL31276129 | 0.81 | HPGD (0.49) | HPGDTSHRHSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL9720594 | 0.78 | L3MBTL1 (0.50) | HSP90AB1MAPK1LMNASMN1; SMN2TDP1 | |
| SCHEMBL7299202 | 0.77 | HPGD (0.45) | HPGDTSHRHSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL1919502 | 0.75 | TDP1 (0.50) | HPGDCYP1A2KDM4EKMT2ALMNA | |
| SCHEMBL6667907 | 0.75 | ALDH1A1 (0.43) | HPGDMAPK1CYP1A2KDM4EKMT2A | |
| SCHEMBL1536288 | 0.74 | HTT (0.55) | HPGDTSHRHSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL16870396 | 0.74 | KEAP1 (0.47) | HPGDTSHRHSP90AA1HSP90AB1MAPK1 | |
| SCHEMBL3671946 | 0.74 | HPGD (0.50) | HPGDHSP90AA1HSP90AB1MAPK1CYP1A2 | |
| SCHEMBL16870471 | 0.74 | HPGD (0.49) | HPGDTSHRHSP90AA1HSP90AB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180065976-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
| US-9777013-B2 | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160185791-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185791-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | UNC119, UNC93B1, RIOX2 | HPGD 3834/4885TSHR 3282/4885HSP90AA1 1099/4885 |
| US-20180065976-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | UNC119, UNC93B1, RIOX2 | HPGD 3667/4885TSHR 3639/4885HSP90AA1 867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.