SCHEMBL7299289

SCHEMBL7299289

CCCCc1nc(C(O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.67
AGTR2 P50052 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7304972 0.91 AGTR1 (0.68) AGTR1AGTR2
SCHEMBL27368393 0.90 PPARG (0.54) AGTR1AGTR2
SCHEMBL7300853 0.90 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL7308702 0.89 AGTR1 (0.61) AGTR1AGTR2
Hydrochloric Acid SCHEMBL7299732 0.89 AGTR1 (0.60) AGTR1AGTR2
SCHEMBL708 0.86 AGTR1 (0.80) AGTR1AGTR2
SCHEMBL7310170 0.86 AGTR1 (0.64) AGTR1AGTR2
SCHEMBL7301054 0.85 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL9468705 0.85 AGTR1 (0.78) AGTR1AGTR2
SCHEMBL7298585 0.85 AGTR1 (0.72) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1045770-C Process for preparing 1-biphenylmethylimidazole derivatives SANKYO CO (JP) 1999-10-20 CN disclosed
US-5646171-A HYPOTENSIVE AGENTS SANKYO COMPANY, LIMITED (JP) 1997-07-08 US disclosed
US-5616599-A HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER SANKYO COMPANY, LIMITED (JP) 1997-04-01 US disclosed
EP-0545912-A2 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use Sankyo Company Limited (JP) 1993-06-09 EP disclosed
EP-0503785-A1 1-Biphenylimidazole derivatives, their preparation and their therapeutic use Sankyo Company Limited (JP) 1992-09-16 EP disclosed