SCHEMBL7299462

SCHEMBL7299462

CC(C=O)C(=O)N1CCOCC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.47
PKM P14618 1/20 0.47
CYP3A4 P08684 1/20 0.46
CYP2C19 P33261 1/20 0.46
GAA P10253 2/20 0.45
KMT2A Q03164 2/20 0.44
MAPT P10636 2/20 0.43
TSHR P16473 2/20 0.43
ALDH1A1 P00352 2/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA9 Q16790 1/20 0.42
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MEN1 O00255 1/20 0.41
TP53 P04637 1/20 0.41
HSP90AA1 P07900 1/20 0.41
HSP90AB1 P08238 1/20 0.41
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23718824 0.82 SMN1; SMN2 (0.46) SMN1; SMN2PKMCYP3A4CYP2C19GAA
SCHEMBL17901794 0.82 SMN1; SMN2 (0.46) SMN1; SMN2PKMCYP3A4CYP2C19GAA
SCHEMBL7304374 0.81 HPGD (0.40) SMN1; SMN2GAAKMT2AMAPTALDH1A1
SCHEMBL7284757 0.81 SMN1; SMN2 (0.44) SMN1; SMN2PKMCYP3A4CYP2C19GAA
SCHEMBL7346646 0.79 ALDH1A1 (0.41) SMN1; SMN2GAAMAPTALDH1A1HPGD
SCHEMBL738198 0.79 SMN1; SMN2 (0.54) SMN1; SMN2PKMCYP3A4CYP2C19GAA
SCHEMBL7299020 0.78 CYP1A2 (0.46) CYP2C19ALDH1A1HPGDALOX15HSD17B10
SCHEMBL762984 0.77 SMN1; SMN2 (0.52) SMN1; SMN2PKMCYP3A4CYP2C19GAA
SCHEMBL13912231 0.77 SMN1; SMN2 (0.58) SMN1; SMN2PKMCYP3A4CYP2C19GAA
SCHEMBL5778346 0.77 SMN1; SMN2 (0.52) SMN1; SMN2PKMCYP3A4CYP2C19GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6008228-A COMPRISING A MIXTURE OF CARRIER MONOGLYCERIDES OF MEDIUM CHAIN-FATTY ACIDS HOFFMAN-LA ROCHE INC. (US) 1999-12-28 US disclosed
EP-0594540-B1 Antiretroviral acyl compounds CIBA GEIGY AG (CH) 1998-04-01 EP disclosed
EP-0831826-A1 PHARMACEUTICAL COMPOSITION COMPRISING A PROTEINASE INHIBITOR AND A MONOGLYCERIDE F. HOFFMANN-LA ROCHE AG (CH) 1998-04-01 EP disclosed
WO-1996039142-A1 PHARMACEUTICAL COMPOSITION COMPRISING A PROTEINASE INHIBITOR AND A MONOGLYCERIDE F. HOFFMANN-LA ROCHE AG (CH) 1996-12-12 WO disclosed
EP-0594540-A1 Antiretroviral acyl compounds CIBA-GEIGY AG (CH) 1994-04-27 EP disclosed