Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300764 | 0.85 | MAPT (0.50) | DRD2SIGMAR1SLC6A4SLC6A3SYK | |
| SCHEMBL25556864 | 0.78 | DRD2 (0.44) | DRD2SIGMAR1SLC6A4SLC6A3HTR2C | |
| SCHEMBL8636443 | 0.78 | DRD2 (0.50) | DRD2SIGMAR1TSHRSLC6A4SLC6A3 | |
| SCHEMBL615579 | 0.78 | DRD2 (0.50) | DRD2SIGMAR1SLC6A4SLC6A3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6734307 | 0.76 | DRD2 (0.49) | DRD2SIGMAR1SLC6A4SLC6A3SMN1; SMN2 | |
| SCHEMBL23589341 | 0.74 | TSHR (0.50) | SIGMAR1TSHRALOX15ALOX12SLC6A4 | |
| SCHEMBL2271090 | 0.71 | DRD2 (0.55) | DRD2SIGMAR1CYP2C19 | |
| SCHEMBL18294780 | 0.71 | PDE2A (0.41) | NPC1RAB9ALMNA | |
| SCHEMBL8806322 | 0.71 | DRD2 (0.46) | DRD2SIGMAR1SLC6A4SMN1; SMN2NPC1 | |
| SCHEMBL1464755 | 0.70 | CYP2C19 (0.42) | TSHRSMN1; SMN2NPC1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459256-B1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GMBH (DE) | 1995-07-12 | — | — | EP | disclosed |
| US-5232931-A | OXAZOLIDINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0459256-A1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GmbH (DE) | 1991-12-04 | — | — | EP | disclosed |