Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299697 | 0.85 | DRD2 (0.47) | MAPTKDM4EALDH1A1MEN1MITF | |
| SCHEMBL615579 | 0.75 | DRD2 (0.50) | ALDH1A1MEN1GAAMAPK1KMT2A | |
| SCHEMBL8636443 | 0.75 | DRD2 (0.50) | MAPTKDM4EALDH1A1MEN1GAA | |
| Hydrochloric Acid SCHEMBL6734307 | 0.74 | DRD2 (0.49) | ALDH1A1MEN1GAAMAPK1KMT2A | |
| SCHEMBL25556864 | 0.70 | DRD2 (0.44) | MAPTKDM4EALDH1A1DRD2SIGMAR1 | |
| SCHEMBL18294780 | 0.69 | PDE2A (0.41) | NPC1RAB9A | |
| SCHEMBL31628136 | 0.69 | ALDH1A1 (0.56) | MAPTKDM4EALDH1A1MEN1MITF | |
| SCHEMBL12044484 | 0.69 | ALDH1A1 (0.63) | MAPTKDM4EALDH1A1MEN1MITF | |
| SCHEMBL31628073 | 0.69 | TSHR (0.49) | MAPTKDM4EALDH1A1MEN1MITF | |
| SCHEMBL8806322 | 0.69 | DRD2 (0.46) | MAPTSMN1; SMN2DRD2SIGMAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459256-B1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GMBH (DE) | 1995-07-12 | — | — | EP | disclosed |
| US-5232931-A | OXAZOLIDINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0459256-A1 | Oxazolidinones with CNS-depressant activity | MERCK PATENT GmbH (DE) | 1991-12-04 | — | — | EP | disclosed |