Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 13/20 | 0.67 |
| ▸ | CYP11B2 | P19099 | 13/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501876 | 0.78 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL28326883 | 0.76 | CYP11B1 (0.68) | CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL12695592 | 0.75 | BACE1 (0.57) | CYP11B1CYP11B2ADORA1CYP17A1MEN1 | |
| SCHEMBL31149547 | 0.75 | ADORA1 (0.41) | CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL29501832 | 0.74 | CYP11B1 (0.78) | CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL4214556 | 0.74 | CYP11B1 (0.78) | CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6 | |
| Hydrochloric Acid SCHEMBL8503236 | 0.73 | CYP11B1 (0.76) | CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL21215634 | 0.73 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL7264558 | 0.72 | CYP11B2 (0.64) | CYP11B1CYP11B2CYP17A1DYRK1A | |
| SCHEMBL5425408 | 0.72 | CYP11B1 (0.65) | CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898872-A | Imidazo[4,5-b]pyridyl quinolone cardiac stimulants | PFIZER INC. (US) | 1990-02-06 | — | — | US | disclosed |
| EP-0290153-A1 | Heterobicyclic quinolone derivatives | Pfizer Limited (GB) | 1988-11-09 | — | — | EP | disclosed |