Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295919 | 0.90 | KMT2A (0.57) | GAAPOLBKMT2ALDHATSHR | |
| SCHEMBL7278749 | 0.83 | CYP3A4 (0.61) | GAACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7300404 | 0.82 | POLB (0.60) | GAACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL16879017 | 0.77 | LDHA (0.54) | GAACYP2C9CYP2C19POLBKMT2A | |
| SCHEMBL5706152 | 0.77 | ACACB (0.58) | GAACYP2C9CYP2C19KMT2AATM | |
| SCHEMBL16879018 | 0.77 | LDHA (0.54) | GAACYP2C9CYP2C19POLBKMT2A | |
| SCHEMBL6662892 | 0.77 | ACACB (0.58) | GAACYP2C9CYP2C19KMT2AATM | |
| SCHEMBL8645164 | 0.74 | LDHA (0.57) | KMT2ALDHA | |
| SCHEMBL13033619 | 0.74 | LDHA (0.57) | KMT2ALDHA | |
| SCHEMBL9832460 | 0.74 | LDHA (0.50) | GAACYP2C9CYP2C19KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |