Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.58 |
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5706152 | 1.00 | ACACB (0.58) | ACACBLDHAKMT2AITGB3ITGA2B | |
| SCHEMBL11674845 | 0.90 | ACACB (0.54) | ACACBLDHAKMT2AITGB3ITGA2B | |
| SCHEMBL14370512 | 0.90 | ACACB (0.54) | ACACBLDHAKMT2AITGB3ITGA2B | |
| SCHEMBL12330296 | 0.89 | ACACB (0.59) | ACACBLDHAKMT2AITGB3ITGA2B | |
| SCHEMBL863032 | 0.88 | KMT2A (0.51) | ACACBKMT2AITGB3ITGA2BGAA | |
| SCHEMBL6438360 | 0.88 | ITGB3 (0.64) | ACACBLDHAKMT2AITGB3ITGA2B | |
| SCHEMBL4361126 | 0.88 | ITGB3 (0.64) | ACACBLDHAKMT2AITGB3ITGA2B | |
| SCHEMBL16879018 | 0.88 | LDHA (0.54) | ACACBLDHAKMT2AGAARAB9A | |
| SCHEMBL16879017 | 0.88 | LDHA (0.54) | ACACBLDHAKMT2AGAARAB9A | |
| SCHEMBL10660397 | 0.88 | ITGB3 (0.64) | ACACBLDHAKMT2AITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030854-B1 | CATALYSTS FOR ASYMMETRIC SYNTHESIS CONTAINING RIGID CHIRAL LIGANDS | PENN STATE RES FOUND (US) | 2004-08-18 | — | — | EP | disclosed |
| US-6380416-B2 | CHIRAL BIDENTATE PHOSPHINE LIGANDS WITH CYCLIC RINGS TO RESTRICT CONFORMATIONAL FLEXIBILITY OF THE LIGANDS TO ENHANCE EFFICIENCY; STEREOSELECTIVE HYDROGENATION OF KETONES TO ALCOHOLS, AND A-ACETOAMIDOCINNAMIC ACID TO ACYLAMINO ACIDS | THE PENN STATE RESEARCH FOUNDATION | 2002-04-30 | — | — | US | disclosed |
| US-20010047113-A1 | Chiral bidentate phosphine ligands with cyclic rings to restrict conformational flexibility of the ligands to enhance efficiency; stereoselective hydrogenation of ketones to alcohols, and a-acetoamidocinnamic acid to acylamino acids | THE PENN STATE RESEARCH FOUNDATION | 2001-11-29 | — | — | US | disclosed |
| EP-1129076-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-05 | — | — | EP | disclosed |
| US-6278024-B1 | AS CATALYSTS FOR ASSYMETRIC SYNTHESIS | THE PENN STATE RESEARCH FOUNDATION | 2001-08-21 | — | — | US | disclosed |
| US-6207868-B1 | BASED ON CHIRAL BIDENTATE PHOSPHINE LIGANDS WITH CYCLIC RING STRUCTURES TO RESTRICT CONFORMATIONAL FLEXIBILITY, ASYMMETRIC SYNTHESIS OF ALCOHOLS BY ENANTIOSELECTIVE HYDROGENATION OF KETONES CATALYZED BY THE CHIRAL LIGANDS | THE PENN STATE RESEARCH FOUNDATION | 2001-03-27 | — | — | US | disclosed |
| CN-1281460-A | Catalysts for asymmetric synthesis containing rigid chiral ligands | PENN STATE RES FOUND (US) | 2001-01-24 | — | — | CN | disclosed |
| EP-1030854-A2 | CATALYSTS FOR ASYMMETRIC SYNTHESIS CONTAINING RIGID CHIRAL LIGANDS | THE PENN STATE RESEARCH FOUNDATION (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-2000029380-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2000-05-25 | — | — | WO | disclosed |
| US-5981521-A | USEFUL FOR TREATING VARIOUS HORMONE DEPENDENT DISEASES, INCLUDING PROSTATE CANCER, ENDOMETRIOSIS, UTERINE FIBROIDS, PRECOCIOUS PUBERTY, BENIGN PROSTATE HYPERTROPY AND IN VITRO FERTILIZATION | ABBOTT LABORATORIES (US) | 1999-11-09 | — | — | US | disclosed |
| WO-1999024443-A2 | CATALYSTS FOR ASYMMETRIC SYNTHESIS CONTAINING RIGID CHIRAL LIGANDS | THE PENN STATE RESEARCH FOUNDATION (US) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047113-A1 | Chiral bidentate phosphine ligands with cyclic rings to restrict conformational flexibility of the ligands to enhance efficiency; stereoselective hydrogenation of ketones to alcohols, and a-acetoamidocinnamic acid to acylamino acids | ADH1A, AASDHPPT, AADAT | ACACB 44/4885LDHA 254/4885KMT2A 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.