Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304193 | 0.97 | ADRB1 (0.49) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL7293833 | 0.95 | ADRB1 (0.48) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL7303937 | 0.93 | LMNA (0.51) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL7302577 | 0.89 | LMNA (0.53) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL7302884 | 0.89 | ADRB1 (0.52) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL9687578 | 0.89 | ADRB1 (0.46) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL7299736 | 0.88 | KMT2A (0.45) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL7300125 | 0.87 | LMNA (0.52) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL9687378 | 0.86 | LMNA (0.46) | ADRB1LMNAKMT2ACYP1A2CYP2D6 | |
| SCHEMBL7296328 | 0.86 | LMNA (0.47) | ADRB1LMNAKMT2ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |