Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | REN | P00797 | 5/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10444524 | 0.86 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7290790 | 0.83 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7324970 | 0.83 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7300835 | 0.82 | KLK5 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10521852 | 0.81 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7290892 | 0.80 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7303392 | 0.79 | KLK5 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5838739 | 0.79 | ATM (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7293840 | 0.77 | KLK5 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7294708 | 0.77 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | claimed |
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |