Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301785 | 0.95 | LMNA (0.52) | MAPTALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL7298727 | 0.87 | MEN1 (0.56) | MAPTALDH1A1LMNAL3MBTL1HTT | |
| SCHEMBL7308785 | 0.85 | MME (0.44) | ALDH1A1LMNAHTTMAPK1TP53 | |
| SCHEMBL7305542 | 0.82 | LMNA (0.53) | MAPTALDH1A1LMNAHTTTP53 | |
| SCHEMBL7307895 | 0.78 | LMNA (0.55) | MAPTALDH1A1LMNAHTTTP53 | |
| SCHEMBL7308721 | 0.77 | MAPT (0.58) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7307483 | 0.77 | MAPT (0.65) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| Lithium Ion SCHEMBL7304536 | 0.75 | MME (0.42) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7303833 | 0.74 | LMNA (0.58) | MAPTALDH1A1LMNACYP2C9HTT | |
| SCHEMBL7308841 | 0.73 | LMNA (0.56) | ALDH1A1LMNACYP2C9HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |