Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | PTPRB | P23467 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308721 | 0.91 | MAPT (0.58) | LMNATP53SMN1; SMN2ALDH1A1PTPRB | |
| SCHEMBL7307957 | 0.90 | MME (0.56) | ALDH1A1PTPRBCTSSCTSLCTSB | |
| SCHEMBL7303833 | 0.89 | LMNA (0.58) | LMNATP53HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL7306211 | 0.88 | CTSS (0.52) | PTPRBCTSSCTSLCTSBCTSK | |
| SCHEMBL7305757 | 0.88 | MEN1 (0.63) | LMNATP53SMN1; SMN2ALDH1A1PTPRB | |
| SCHEMBL7443382 | 0.83 | TACR1 (0.53) | LMNATP53CTSSCTSLCTSB | |
| SCHEMBL27677878 | 0.82 | CTSS (0.57) | PTPRBCTSSCTSLCTSBCTSK | |
| SCHEMBL7308749 | 0.82 | LMNA (0.64) | LMNATP53HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL3814091 | 0.82 | CTSS (0.57) | PTPRBCTSSCTSLCTSBCTSK | |
| SCHEMBL944756 | 0.81 | SMN1; SMN2 (0.73) | LMNATP53SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |