Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306783 | 0.94 | HTR1A (0.46) | HTR1APPARGPPARADRD3KDM4E | |
| SCHEMBL7305222 | 0.94 | HTR1A (0.47) | HTR1APPARGPPARADRD3KDM4E | |
| SCHEMBL7299031 | 0.92 | HTR1A (0.46) | HTR1APPARGPPARADRD3KDM4E | |
| SCHEMBL7365452 | 0.89 | PPARG (0.43) | HTR1APPARGPPARADRD3SIGMAR1 | |
| SCHEMBL7360979 | 0.89 | DRD3 (0.44) | HTR1APPARGPPARADRD3KDM4E | |
| SCHEMBL7299099 | 0.89 | HTR1A (0.48) | HTR1APPARGPPARADRD3KDM4E | |
| SCHEMBL7330914 | 0.87 | HTR1A (0.46) | HTR1APPARGPPARADRD3KDM4E | |
| SCHEMBL7295815 | 0.87 | PPARG (0.44) | HTR1APPARGPPARADRD3KDM4E | |
| SCHEMBL7310058 | 0.85 | PPARG (0.42) | HTR1APPARGPPARADRD3KDM4E | |
| SCHEMBL7301503 | 0.83 | HTR7 (0.43) | HTR1APPARGPPARADRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |