Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290710 | 0.89 | TSHR (0.76) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL7298260 | 0.86 | ALDH1A1 (0.73) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL7300309 | 0.86 | TSHR (0.73) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL22986510 | 0.86 | TSHR (0.72) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL26036355 | 0.85 | TSHR (0.71) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL1938827 | 0.84 | ALDH1A1 (1.00) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL29766970 | 0.84 | ALDH1A1 (1.00) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL7298095 | 0.82 | TSHR (0.78) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL22986511 | 0.80 | TSHR (0.70) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL7297642 | 0.79 | MAPT (0.73) | TSHRCYP2D6CYP2C19CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | claimed |
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | disclosed |