Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 10/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292953 | 0.88 | KDM4E (0.38) | ABCB1MALT1MAOBABCC9KDM4E | |
| SCHEMBL7297213 | 0.81 | KCNE1 (0.34) | ABCB1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7290029 | 0.76 | AKR1B1 (0.37) | MALT1MAOBCYP2D6 | |
| SCHEMBL7298546 | 0.76 | AHR (0.35) | MAOB | |
| SCHEMBL9583441 | 0.73 | KDM4E (0.37) | ABCB1MALT1KDM4E | |
| SCHEMBL25387439 | 0.71 | DAO (0.41) | ABCB1MALT1MAOBABCC9DAO | |
| SCHEMBL30514069 | 0.71 | DAO (0.41) | ABCB1MALT1MAOBABCC9DAO | |
| SCHEMBL7299826 | 0.71 | AKR1B1 (0.42) | MALT1 | |
| SCHEMBL7300321 | 0.70 | ABCB1 (0.38) | ABCB1MALT1MAOBABCC9DAO | |
| SCHEMBL7292321 | 0.69 | PKM (0.35) | ABCB1MAOBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |