SCHEMBL7300353

SCHEMBL7300353

COc1ccc(C=Cc2ccncc2)c2c1OC1(C=C2)CCCC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.45
LMNA P02545 1/20 0.45
CYP1A1 P04798 5/20 0.43
CYP1B1 Q16678 5/20 0.43
HPGD P15428 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
ALDH1A1 P00352 1/20 0.41
KDM4E B2RXH2 2/20 0.40
HSD17B10 Q99714 1/20 0.40
CYP1A2 P05177 4/20 0.36
CYP2D6 P10635 2/20 0.36
NPC1 O15118 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
RAB9A P51151 1/20 0.36
ODC1 P11926 2/20 0.33
ROCK2 O75116 1/20 0.33
MAP4K4 O95819 1/20 0.33
PRKACA P17612 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8326536 1.00 MAPT (0.45) MAPTLMNACYP1A1CYP1B1HPGD
SCHEMBL5723204 0.80 ALDH1A1 (0.35) MAPTLMNAHPGDSMN1; SMN2ALDH1A1
SCHEMBL5723068 0.79 ALDH1A1 (0.35) LMNAHPGDSMN1; SMN2ALDH1A1KDM4E
SCHEMBL7303717 0.79 SMN1; SMN2 (0.35) MAPTLMNACYP1A1CYP1B1HPGD
SCHEMBL7303723 0.79 SMN1; SMN2 (0.35) MAPTLMNACYP1A1CYP1B1HPGD
SCHEMBL5722752 0.75 MAPT (0.47) MAPTLMNACYP1A1CYP1B1HPGD
SCHEMBL5723570 0.75 MAPT (0.47) MAPTLMNACYP1A1CYP1B1HPGD
SCHEMBL5722755 0.75 MAPT (0.47) MAPTLMNACYP1A1CYP1B1HPGD
SCHEMBL6838147 0.74 MAPT (0.46) MAPTLMNACYP1A1CYP1B1HPGD
SCHEMBL5723278 0.74 MAPT (0.46) MAPTLMNACYP1A1CYP1B1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0819689-A1 5-substituted (2H) chromenes Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1998-01-21 EP disclosed